Pregabalin 0.6% Ophthalmic Solution

Pregabalin 0.6% sterile ophthalmic solution is for topical ophthalmic use and used for ocular pain and glaucoma.

• Volume: 5ml
• Concentration: 0.6%
• We exclusively compound Pregabalin ophthalmic solution for ophthalmic use only
• Compounded in a sterile compounding facility that is <795>, <797> and <800> chapter compliant

Contact us to inquire about customizations and for detailed pricing information. Please note that all compounds require a valid, patient-specific prescription.

References: 

1. Paik DW, Lim DH, Chung TY. Effects of taking pregabalin (Lyrica) on the severity of dry eye, corneal sensitivity and pain after laser epithelial keratomileusis surgery. Br J Ophthalmol. 2022;106(4):474-479. doi:10.1136/bjophthalmol-2020-317570
2. Shen X, Chen X, He Y, Xu H, Zhu J. Efficacy and safety of pregabalin in eye pain: A systematic review. Medicine (Baltimore). 2023;102(6):e32875. doi:10.1097/MD.0000000000032875
3. Paik DW, Lim DH, Chung TY. Effects of taking pregabalin (Lyrica) on the severity of dry eye, corneal sensitivity and pain after laser epithelial keratomileusis surgery. Br J Ophthalmol. 2022;106(4):474-479. doi:10.1136/bjophthalmol-2020-317570
4. Tei Y, Mikami Y, Ito M, et al. Pathogenic Mechanism of Dry Eye-Induced Chronic Ocular Pain and a Mechanism-Based Therapeutic Approach. Invest Ophthalmol Vis Sci. 2022;63(1):7. doi:10.1167/iovs.63.1.7
5. Wang J, Wang H, Dang Y. Rho-Kinase Inhibitors as Emerging Targets for Glaucoma Therapy. Ophthalmol Ther. 2023;12(6):2943-2957. doi:10.1007/s40123-023-00820-y
6. TRAVATAN Z [package insert]. Published online 2017. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021994s012lbl.pdf
7. Ibrahim MM, Maria DN, Mishra SR, Guragain D, Wang X, Jablonski MM. Once Daily Pregabalin Eye Drops for Management of Glaucoma. ACS Nano. 2019;13(12):13728-13744. doi:10.1021/acsnano.9b07214
8. Chintalapudi SR, Maria D, Di Wang X, et al. Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility. Nat Commun. 2017;8(1):1755. doi:10.1038/s41467-017-00837-5
9. Maria DN, Ibrahim MM, Kim MJ, et al. Evaluation of Pregabalin bioadhesive multilayered microemulsion IOP-lowering eye drops. J Controlled Release. 2024;373:667-687. doi:10.1016/j.jconrel.2024.07.061
10. Cammalleri M, Amato R, Olivieri M, et al. Effects of Topical Gabapentin on Ocular Pain and Tear Secretion. Front Pharmacol. 2021;12:671238. doi:10.3389/fphar.2021.671238
11. Bockbrader HN, Wesche D, Miller R, Chapel S, Janiczek N, Burger P. A comparison of the pharmacokinetics and pharmacodynamics of pregabalin and gabapentin. Clin Pharmacokinet. 2010;49(10):661-669. doi:10.2165/11536200-000000000-00000
12. Pakravan M, Roshani M, Yazdani S, Faramazi A, Yaseri M. Pregabalin and gabapentin for post-photorefractive keratectomy pain: a randomized controlled trial. Eur J Ophthalmol. 2012;22 Suppl 7:S106-113. doi:10.5301/ejo.5000143
13. Dauri M, Faria S, Gatti A, Celidonio L, Carpenedo R, Sabato AF. Gabapentin and pregabalin for the acute post-operative pain management. A systematic-narrative review of the recent clinical evidences. Curr Drug Targets. 2009;10(8):716-733. doi:10.2174/138945009788982513

Learn More: Pregabalin Eye Drops for Ocular Pain and Glaucoma