Low Dose Naltrexone (LDN)

Naltrexone is an FDA-approved opioid antagonist used to manage alcohol use or opioid use disorder at a dose of 50 mg, but at lower doses (typically ≤ 4.5 mg), it elicits different therapeutic effects in various patient populations. Although naltrexone has been used for decades, the indications of LDN have only begun to emerge, especially in the past several years.

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Low Dose Naltrexone (LDN)

How We Can Help with Low Dose Naltrexone

VLS Pharmacy is a member of the LDN Research Trust, a non-profit organization that
is doing important work to raise awareness about LDN treatment for auto-immune disease
and cancer as well as to raise funds for investing in LDN clinical trials.

At VLS Pharmacy and New Drug Loft, we offer various LDN treatment options,
including capsules and sublingual troches 0.5 – 4.5 mg, topical creams and gels,
nasal spray, and vaginal gel and cream.

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How LDN Works

  • An up-regulation of endorphins to help modulate the immune system response

  • Modulation of unwanted cell proliferation

  • An increase in the production of endogenous opioid peptides which can help promote healing and reduce inflammation

  • Low-dose naltrexone binds to toll-like receptors (TLR) to inhibit proinflammatory cytokines and antagonizes the production of NF-kB to help reduce inflammation

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Indications of Low Dose Naltrexone

The conditions are listed below, select the category a condition come under to open up a further list:

  • Chronic pain
  • Complex regional pain syndrome
  • Crohn’s disease
  • Fibromyalgia
  • Lupus
  • Multiple sclerosis
  • Post-Lyme’s arthritis
  • Ulcerative colitis

Learn more about how low dose Naltrexone could be of benefit for autoimmune disorders ›.

  • Alopecia universalis/areata
  • Burn injury
  • Cholestasis
  • Dermatomyositis
  • Hailey-Hailey disease
  • Lichen planopilaris
  • Prurigo nodularis
  • Pruritus/eczema
  • Psoriasis
  • Systemic sclerosis
  • Vitiligo

Learn more about how low dose Naltrexone could be used in dermatology ›.

  • Fibromyalgia
  • Irritable bowel syndrome (IBS)
  • Menopause symptoms
  • Burning mouth syndrome
  • Chronic pain
  • Insomnia
  • Polycystic ovary syndrome (PCOS)
  • Premenstrual syndrome (PMS)
  • Vulvodynia

Learn more about how low dose Naltrexone could be of benefit for women's health ›.

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Dosing of Low Dose Naltrexone

LDN Dose Titration Schedule

Naltrexone is currently only commercially available as 50 mg tablets, patients may try to create their own LDN dosages by cutting up these tablets. Some patients may rely on Internet sources that explain how to do this or create a solution and then divide the liquid doses (23). As accurate dosing is critical to the success of any therapy, this will almost certainly lead to inaccurate day-to-day dosing. VLS Pharmacy & New Drug Loft can create LDN formulations with patient-specific dosing and administration routes, helping ensure that patients are receiving accurate doses.

Accurate LDN Dose Titration Schedule

There is no agreed upon effective dose of LDN, so prescribers will likely have to titrate the dose to determine the maximally effective dose for their individual patients.16 LDN is typically titrated up from 1.5 mg/day to up to 4.5 mg/day over the course of at least one month. Regardless of which titration schedule is prescribed, our pharmacists will tailor it to meet each individual patient’s specific needs.

Side Effects and Tolerance of Low Dose Naltrexone (LDN)

Overall, LDN is well-tolerated by most users. However, as with most medications, your patients may experience side effects. Some users report that LDN causes them to dream more vividly. Other patients complain that it causes insomnia; in these cases, users can switch to a morning dose. Less common side effects include an increase in anxiety, sweating, GI upset and headaches. Interestingly, some patients see a decrease in anxiety and depression and an increase in mental clarity.

While it is safe to drink alcohol while taking LDN, it isn’t recommended. In fact, treatment for alcoholism is one of the uses for Naltrexone when applied at higher doses.

It’s important to establish an optimal dose for your patients by gradually increasing the dosage while assessing their tolerance. Both the dosage and the rate at which it can be increased is highly patient-specific and depends on factors such as gender, body size, the condition being treated, and the patient’s tolerance of the drug. Realistically, your patients should expect to take LDN for a minimum of two weeks before experiencing an alleviation of symptoms.

As a 503A compounding pharmacy specializing in sterile and non-sterile compounding, we will support you and your patients by creating safe, individualized, and effective pharmaceutical therapies. All formulations are compounded with high-quality pharmaceutical-grade APIs sourced directly from PCCA, the leader of superior-quality APIs.

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Lisa Weiner IntratorLisa Weiner Intrator
18:27 17 Aug 23
Wonderful staff; wonderful pharmacy
Leslie AdismanLeslie Adisman
14:25 08 May 23
Finally, I have found a great pharmacy that offers excellent care, good customer service, and, most importantly, knowledgeable pharmacists. For years, I've been struggling with the ineptitude of the large chain stores that have pharmacies located inside of them. You can guess their names. There are only two of them, although they are located on almost every block in NYC. Because New Drug Loft accepts my health insurance, I will never set foot in the two drugstores unless I am forced to.
Paula HPaula H
21:42 15 Dec 22
Everything about this place is wonderful!
Makayla MurphyMakayla Murphy
23:11 21 Nov 22
Great indie pharmacy with lots of offerings
Laura YooLaura Yoo
16:30 19 Nov 22
Liliana GillLiliana Gill
11:48 03 Oct 21
Wonderful place with an amazing staff. They are more like family. Ben cares for his customers. Only reason I didn't give the place a five is because sometimes you have to wait for the medication to come for a while but that's not their fault as much as the manufacturer 's and that my medications are a pain in the neck to get. It's a great place and I honestly recommend it. When I post a review I really mean what I say. I've been going to them for several years now. It's a wonderful break from the impersonal chain store and I think the staff makes that difference. Have a nice day.🤗
NancyNancy
22:58 03 Aug 21
New Drug Loft pharmacy has always been my place of choice for all my needs. They have such a huge selection of products and the service by all the workers is outstanding. I've moved recently but every time I come to NY I can't go without visiting this great pharmacy. There new location is twice the size from the before. Congratulations in your move. Way to go, it's beautiful.
Vallery DazaVallery Daza
19:18 29 Jul 21
I’ve been working in this pharmacy for 6 months now and all I can say is that it’s an honor to be working here. Observing everyone in this work place since day one, I’ve seen how much they care about each and every customer which is why we have so many loyal customers come in our store all the time. They will literally make you feel like family. We go from compounding medicine to retail… you will not be disappointed with New Drug aloft..come visit us!
Sandra HaugenSandra Haugen
22:52 19 Jul 21
I was recently in NY and had the pleasure of visiting my favorite pharmacy, New Drug Loft. They have recently moved over from their old location to a new address on 2nd Avenue. It’s a beautiful new store at a great location. If you are in need of essentials or a place to get your prescriptions filled, this is your place. I have been coming here through the years and will continue to do so because of the personal service I receive. The faces and voices are friendly and always willing to help. They have a vast variety of toiletries, soaps, perfumes, creams and lotions. Most of them high end and very convenient to find. They are a compounding pharmacy as well, which are few and far between. I much prefer to shop here instead of one of the large cold corporate chains that just don’t know how to treat their customers. I encourage you to stop in and check it out if you are in the neighborhood. You won’t regret it!
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